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VIP Genotyping Diagnostic Platform

 

 

VIP Technology Overview

Platinum Cleanroom Platform Package

Gold Cleanroom Platform Package

Silver Cleanroom Platform Package

Bronze Cleanroom Platform Package

 

 Application Areas
Arrayit VIP™ technology allows the identification of any amplified nucleic acid sequence from any organism. The main clinical application areas include population screening, disease screening, disease diagnosis, parentage testing, human leukocyte antigen (HLA) typing, blood typing, infectious disease diagnosis, forensics, and neonatal and adult screening. VIP™ technology can also be applied to a myriad of research areas including genetic studies in human, mouse, rat, higher plants, bacteria and viruses aimed at detecting specific sequences, or minor sequence variants including single nucleotide polymorphisms (SNPs), mutations, insertions, deletions and insertion-deletion (indel) mutations. VIP™

Technology Overview
Arrayit VIP™ technology is a universal microarray analysis platform for nucleic acid-based genetic screening, testing, diagnostics, genotyping and single nucleotide polymorphism (SNP) analysis. Arrayit technology allows hybridization-based analysis of SNPs, mutations, deletions, insertion-deletion mutations (indels), and other minor sequence variants from any organism of interest. Arrayit also allows detection of bacterial and viral sequences as required for the diagnosis of infectious diseases caused by agents such as mycobacterium tuberculosis, cytomegalovirus (CMV), human immunodeficiency virus (HIV), bacillus anthracis, and other pathogens.

Specific genetic loci are amplified by use of the polymerase chain reaction (PCR), printed into a microarray, and hybridized with fluorescent synthetic oligonucleotides. The hybridized microarrays are then scanned for fluorescence emission to derive genotyping information (Figure 1). Normal, carrier and disease genotypes are distinguished easily because slight changes in primary DNA sequence alter hybridization efficiency (Figure 2). Altered hybridization efficiency leads to different fluorescent intensities in the scanned microarray image (Figure 3). Multi-color strategies involving cyanine3 and cyanine5 fluorescent labels can be used to improve the readability and precision of the assays (Figure 3). If performed correctly, the Arrayit method is 100% accurate. A microarray containing 25,000 individual printed features showcases the extraordinary quality of Arrayit® microarrays (Figure 4). Platinum, Gold, Silver and Bronze Cleanroom plans provide integrated environments designed to meet the most exacting clinical and research applications. Visit the Arrayit Diagnostics Division for Platform details.

The Arrayit approach is clear departure from traditional microarray assays that use oligonucleotide capture probes to analyze one or two patient samples at a time. Instead of the patient samples floating in solution, amplified material from each patient is attached at a distinct location to the microarray substrate, allowing massively parallel analysis of multiple patients and multiple loci in a single test. The current printing capacity (>100,000 spots per microarray) enables screening of 10,000 patients at 10 different loci on one chip. Arrayit is the only platform that allows the economical screening of millions of patients per year. This revolutionary "samples down" approach allows all of the costs of the test (hardware, software, labor, kits, reagents, etc.) to be amortized across many patients to provide a cost-effectiveness that is impossible to achieve with traditional methods. Arrayit technology can be scaled down to allow testing of tens or hundreds of samples per chip, rendering it ideal for hospitals and public health facilities that process a relatively small number of samples, but require testing on a daily basis. Arrayit technology is rapid, providing accurate genotyping information within 24-48 hours of receiving a patient sample. In the future, Arrayit is expected to integrate into the larger healthcare picture, enabling physicians and other health care officials to make increasingly better clinical decisions.

 

 

Figure 1. VIP™ Method. The patented Arrayit method is a universal microarray-based platform for genetic screening. Specific chromosomal loci are amplified by use of the polymerase chain reaction (PCR), printed into microarrays, and hybridized with fluorescent oligonucleotides. The fluorescent microarrays are then scanned for fluorescence emission and signal strengths provide genotyping information.

 Figure 2. VIP™ is specific for single nucleotide changes. Amplified DNA segments (black letters) from patients with normal (G/G), carrier (G/A) and disease (A/A) genotypes are identical except at a single nucleotide position, which is G in the normal allele and A (red letter) in the mutated allele. Complementary fluorescent oligonucleotides (green letters) hybridized with different efficiencies to the three samples, producing strong, intermediate and weak signals, respectively, for the normal, carrier and disease patients.

 

Figure 3. VIP™ 2-color strategies. The VIP™ method was used to analyze samples from patients with different disease genotypes. Fluorescent oligonucleotides bearing cyanine5 (red channel) and cyanine3 (green channel) were co-hybridized to a microarray, scanned for cyanine3 and cyanine5 emission, and the fluorescent images were superimposed to produce a composite, 2-color image (bottom panel). The 3 different genotypes are distinguished easily by scoring the red, yellow and green colors.

 

Figure 4. VIP™ microarray with 25,000 features. Arrayit Diagnostics manufacturing and cleanroom technology enable printing of extremely high-quality microarrays, which improves the precision and reliability of the data. Chips containing 25,000 individual features (shown here) allow the simultaneous genotyping of 25,000 different patients at one locus in a single test.

 

Diagnostic Platforms

Arrayit offers a complete line of genetic and protein screening platforms that include both Laboratory and Cleanroom Dx Platforms. Our extensive diagnostics product line meets the most demanding requirements of the rapidly expanding research and commercial genotyping and protein detection markets.

 

 

Arrayit has more than two decades of experience in international commerce, making it easy to ship our Laboratory and Cleanroom Platforms to any destination worldwide. Once the containers reach the customer destination, Platforms are assembled on-location by our highly trained personnel, followed by complete technical training onsite, and unlimited technical assistance post-installation.

Arrayit Diagnostics Platforms
Our platforms are constructed on-location at pharmaceutical and biotechnology companies, hospitals, public health laboratories, universities, and other agencies using Arrayit Diagnostics Technology for genetic screening and diagnostics in their laboratories. Customers choose from eight different packages to accommodate specific applications, budgets and organizational needs.

Platinum Cleanroom Platform Package
Catalog: DPC
Starting price: $2,620,000

The Platinum Cleanroom Platform provides an On-Location Facility consisting of a state-of-the art microarray cleanroom containing a full line of the most advanced microarray and automation equipment in the world designed to genotype up to 5,000,000 patients per annum. The DPC Package includes the following:

  • One year license to use Arrayit VIP™ genotyping technology (US 6,913,879 and international equivalents)
  • One year license to use Arrayit patented printing technology (US 6,101,946 and international equivalents)
  • Class 100 microarray cleanroom 26 ft x 13 ft (32 square meters) with a 6 ft x 6 ft changing room (3.3 square meters), portable design to integrate into existing laboratory space, near-zero particulate composite materials to minimize airborne contamination, high-reflection surface coverings for enhanced optics, ultra-low organic emission surface coverings to minimize gaseous contamination, sliding entrance and exit doors for easy access, double-pane gas-charged glass walls for thermal insulation and increased user safety, hot and cold running water, cleanroom sink and automatic waste water removal system, variable speed fume hood to remove light organic vapors, stand-alone high-capacity air conditioning system to provide rapid and efficient environmental control, custom benches fabricated with ultra-heavy duty construction materials to accommodate industrial-scale manufacturing instruments, systemic and stand-alone ULPA air filtration technology with 0.1 µm and 99.999% particulate removal capacity, adhesive floor mats to trap exogenous particulates, full spectrum overhead lighting, 110- and 220-volt circuitry and easy-access service panel
  • Complete laboratory protocols manual
  • Training and technical assistance
  • Six-month staffing to facilitate the technology transfer process
  • Oligonucleotide design software
  • Sample tracking and data analysis software
  • Microarray printing robot with 210-substrate platen, intuitive graphical user interface, linear drive motion control, optical encoders for ±0.5 µm positional resolution, automated plate stacker and liquid transfer capabilities, calibrated substrate platen for high-precision travel distance, 48-pin printhead, 48 Micro Spotting Pins with 0.25 µl loading volume and 100-125 µm spot size, and overhead air filtration and environmental control for enhanced functionality
  • Microarray scanner for fluorescence detection, 3 µm scanning resolution, intuitive graphical user interface, confocal optics, cyanine3 and cyanine5 dual detection, high-performance PMTs, 24-substrate autoloader, and ultra-high detectivity
  • Arrayit automated liquid handling robot with linear drive motion, optical encoders for ±1.0 µm positional resolution, 96-well and 384-well-dispense heads
  • Thermal cycler work stations, high-throughput PCR amplification, 384-well format, 6,144 PCR reactions per day
  • High-capacity freezer and refrigerator with –30°C and 4°C settings
  • Substrate baking oven
  • Dissecting microscope with 30X magnification
  • Vacuum-based sample preparation system
  • Arrayit hybridization and microarray processing system
  • High performance centrifuge with custom Arrayit rotor, thermal control and vacuum capabilities
  • Arrayit high-performance forced air forced air compressor with 0.1 µm filtration for topical decontamination
  • Arrayit Microarray Substrates, 5,000 optically flat 25 x 76 mm with diagnostic coupling chemistry
  • Arrayit Hybridization Buffer, 200 vials (200 ml) of 1.25X solution
  • Arrayit Printing Buffer, 500 bottles (25 liters) of 2X solution
  • Arrayit ULPA filters, 12 each
  • Arrayit adhesive floor mats, 24 each
  • Arrayit high-performance Tyvek® cleansuits (XXL, XL, L, M, S), 50 each
  • Arrayit protective nitrile cleanroom gloves (L, M, S), 5,000 each

 Gold Cleanroom Platform Package
Catalog: DGC
Starting price: $1,570,000

The Gold Cleanroom Platform provides an On-Location Facility consisting of a state-of-the art microarray cleanroom containing a full line of the most advanced microarray and automation equipment in the world designed to genotype up to 1,000,000 patients per annum. The DGC Package includes the following:

  • One year license to use Arrayit VIP™ genotyping technology (US 6,913,879 and international equivalents)
  • One year license to use Arrayit patented printing technology (US 6,101,946 and international equivalents)
  • Class 100 microarray cleanroom 19 ft x 13 ft (24 square meters) with a 6 ft x 6 ft changing room (3.3 square meters), portable design to integrate into existing laboratory space, near-zero particulate composite materials to minimize airborne contamination, high-reflection surface coverings for enhanced optics, ultra-low organic emission surface coverings to minimize gaseous contamination, sliding entrance and exit doors for easy access, double-pane gas-charged glass walls for thermal insulation and increased user safety, hot and cold running water, cleanroom sink and automatic waste water removal system, variable speed fume hood to remove light organic vapors, stand-alone high-capacity air conditioning system to provide rapid and efficient environmental control, custom benches fabricated with ultra-heavy duty construction materials to accommodate industrial-scale manufacturing instruments, systemic and stand-alone ULPA air filtration technology with 0.1 µm and 99.999% particulate removal capacity, adhesive floor mats to trap exogenous particulates, full spectrum overhead lighting, 110- and 220-volt circuitry and easy-access service panel
  • Complete laboratory protocols manual
  • Training and technical assistance
  • Three-month staffing to facilitate the technology transfer process
  • Oligonucleotide design software
  • Sample tracking and data analysis software
  • Microarray printing robot with 60-substrate platen, intuitive graphical user interface, optical encoders for ±0.5 µm positional resolution, calibrated substrate platen for high-precision travel distance, 48-pin printhead, 48 Micro Spotting Pins pins with 0.25 µl loading volume and 100-125 µm spot size, and overhead air filtration and environmental control for enhanced functionality
  • Microarray scanner for fluorescence detection, 3 µm scanning resolution, intuitive graphical user interface, confocal optics, cyanine3 and cyanine5 dual detection, high-performance PMTs, and ultra-high detectivity
  • Arrayit automated liquid handling robot with linear drive motion, optical encoders for ±1.0 µm positional resolution, 96-well and 384-well-dispense heads
  • Thermal cycler work stations, high-throughput PCR amplification, 384-well format, 3,072 PCR reactions per day
  • High-capacity freezer and refrigerator with –30°C and 4°C settings
  • Substrate baking oven
  • Dissecting microscope with 30X magnification
  • Vacuum-based sample preparation system
  • Arrayit hybridization and microarray processing system
  • High performance centrifuge with custom Arrayit rotor, thermal control and vacuum capabilities
  • Arrayit high-performance forced air forced air compressor with 0.1 µm filtration for topical decontamination
  • Arrayit Microarray Substrates, 2,000 optically flat 25 x 76 mm with diagnostic coupling chemistry
  • Arrayit Hybridization Buffer, 40 vials (40 ml) of 1.25X solution
  • Arrayit Printing Buffer, 100 bottles (5 liters) of 2X solution
  • Arrayit ULPA filters, 8 each
  • Arrayit adhesive floor mats, 24 each
  • Arrayit high-performance Tyvek® cleansuits (XXL, XL, L, M, S), 40 each
  • Arrayit protective nitrile cleanroom gloves (L, M, S), 4,000 each

Silver Cleanroom Platform Package
Catalog: DSC
Starting price: $920,000

The Silver Cleanroom Platform provides a Facility On-Location consisting of a state-of-the art microarray cleanroom containing a full line of the most advanced microarray automation equipment in the world designed to genotype up to 200,000 patients per annum. The DSC Package includes the following:

  • One year license to use Arrayit VIP™ genotyping technology (US 6,913,879 and international equivalents)
  • One year license to use Arrayit patented printing technology (US 6,101,946 and international equivalents)
    Class 100 microarray cleanroom 13 ft x 13 ft (16 square meters) with a 6 ft x 6 ft changing room (3.3 square meters), portable design to integrate into existing laboratory space, near-zero particulate composite materials to minimize airborne contamination, high-reflection surface coverings for enhanced optics, ultra-low organic emission surface coverings to minimize gaseous contamination, sliding entrance and exit doors for easy access, double-pane gas-charged glass walls for thermal insulation and increased user safety, hot and cold running water, compact cleanroom sink and automatic waste water removal system, variable speed fume hood to remove light organic vapors, stand-alone high-capacity air conditioning system to provide rapid and efficient environmental control, custom benches fabricated with ultra-heavy duty construction materials to accommodate industrial-scale manufacturing instruments, systemic and stand-alone ULPA air filtration technology with 0.1 µm and 99.999% particulate removal capacity, adhesive floor mats to trap exogenous particulates, full spectrum overhead lighting, 110- and 220-volt circuitry and easy-access service panel
  • Complete laboratory protocols manual
  • Training and technical assistance
  • One-month staffing to facilitate the technology transfer process
  • Oligonucleotide design software
  • Sample tracking and data analysis software
  • Microarray printing robot with 14-substrate platen, intuitive graphical user interface, ±10 µm positional resolution, calibrated substrate platen for high-precision travel distance, 4-pin printhead, 4 Micro Spotting Pins pins with 0.25 µl loading volume and 100-125 µm spot size, and environmental control for enhanced functionality
    Microarray scanner for fluorescence detection, 3 µm scanning resolution, intuitive graphical user interface, confocal optics, cyanine3 and cyanine5 dual detection, high-performance PMTs, and ultra-high detectivity
  • Thermal cycler work stations, high-throughput PCR amplification, 384-well format, 1,536 PCR reactions per day
  • High-capacity freezer and refrigerator with –30°C and 4°C settings
  • Substrate baking oven
  • Dissecting microscope with 30X magnification
  • Vacuum-based sample preparation system
  • Arrayit hybridization and microarray processing system
  • Arrayit high-performance forced air forced air compressor with 0.1 µm filtration for topical decontamination
  • Arrayit Microarray Substrates, 500 optically flat 25 x 76 mm with diagnostic coupling chemistry
  • Arrayit Hybridization Buffer, 10 vials (10 ml) of 1.25X solution
  • Arrayit Printing Buffer, 25 bottles (1.25 liters) of 2X solution
  • Arrayit ULPA filters, 6 each
  • Arrayit adhesive floor mats, 24 each
  • Arrayit®high-performance Tyvek® cleansuits (XXL, XL, L, M, S), 25 each
  • Arrayit protective nitrile cleanroom gloves (L, M, S), 1,000 each

Bronze Cleanroom Platform Package
Catalog: DBC
Starting price: $770,000

The Bronze Cleanroom Platform provides an On-Location Facility consisting of a state-of-the art microarray cleanroom containing a full line of the most advanced microarray and automation equipment in the world designed to genotype up to 50,000 patients per annum. The DBC Package includes the following:

  • One year license to use Arrayit VIP™ genotyping technology (US 6,913,879 and international equivalents)
  • One year license to use Arrayit patented printing technology (US 6,101,946 and international equivalents)
  • Class 100 microarray cleanroom 6.5 ft x 13 ft (8 square meters) with a 6 ft x 6 ft changing room (3.3 square meters), portable design to integrate into existing laboratory space, near-zero particulate composite materials to minimize airborne contamination, high-reflection surface coverings for enhanced optics, ultra-low organic emission surface coverings to minimize gaseous contamination, sliding entrance and exit doors for easy access, double-pane gas-charged glass walls for thermal insulation and increased user safety, hot and cold running water, compact cleanroom sink and automatic waste water removal system, variable speed fume hood to remove light organic vapors, stand-alone high-capacity air conditioning system to provide rapid and efficient environmental control, custom benches fabricated with ultra-heavy duty construction materials to accommodate industrial-scale manufacturing instruments, systemic and stand-alone ULPA air filtration technology with 0.1 µm and 99.999% particulate removal capacity, adhesive floor mats to trap exogenous particulates, full spectrum overhead lighting, 110- and 220-volt circuitry and easy-access service panel
  • Complete laboratory protocols manual
  • Training and technical assistance
  • One-week staffing to facilitate the technology transfer process
  • Oligonucleotide design software
  • Sample tracking and data analysis software
  • Microarray personal printing robot with 14-substrate platen, intuitive graphical user interface, calibrated substrate platen, 4-pin printhead, 4 Micro Spotting Pins with 0.25 µl loading volume and 100-125 µm spot size, and environmental enclosure for enhanced functionality
  • Microarray scanner for fluorescence detection, 10 µm scanning resolution, intuitive graphical user interface, confocal optics, cyanine3 and cyanine5 dual detection, and high detectivity capabilities
  • Compact refrigerator with 4°C setting
  • Substrate baking oven
  • Dissecting microscope with 30X magnification
  • Vacuum-based sample preparation system
  • Arrayit hybridization and microarray processing system
  • High performance centrifuge with custom Arrayit rotor, thermal control and vacuum capabilities
  • Arrayit high-performance forced air forced air compressor with 0.1 µm filtration for topical decontamination
  • Arrayit Microarray Substrates, 250 optically flat 25 x 76 mm with diagnostic coupling chemistry
  • Arrayit Hybridization Buffer, 5 vials (5 ml) of 1.25X solution
  • Arrayit Printing Buffer, 10 bottles (500 ml) of 2X solution
  • Arrayit ULPA filters, 4 each
  • Arrayit adhesive floor mats, 24 each
  • Arrayit high-performance Tyvek® cleansuits (XXL, XL, L, M, S), 25 each
  • Arrayit protective nitrile cleanroom gloves (L, M, S), 1,000 each

Platinum Laboratory Platform Package
Catalog: DPL
Starting price: $1,375,000

The Platinum Laboratory Platform provides an On-Location Facility consisting of a state-of-the art microarray package containing a full line of the most advanced microarray and automation equipment in the world designed to genotype up to 5,000,000 patients per annum. The DPL Package includes the following:

  • One year license to use Arrayit VIP™ genotyping technology (US 6,913,879 and international equivalents)
  • One year license to use Arrayit patented printing technology (US 6,101,946 and international equivalents)
  • Complete laboratory protocols manual
  • Training and technical assistance
  • Six-month staffing to facilitate the technology transfer process
  • Oligonucleotide design software
  • Sample tracking and data analysis software
  • Microarray printing robot with 210-substrate platen, intuitive graphical user interface, linear drive motion control, optical encoders for ±0.5 µm positional resolution, automated plate stacker and liquid transfer capabilities, calibrated substrate platen for high-precision travel distance, 48-pin printhead, 48 Micro Spotting Pins with 0.25 µl loading volume and 100-125 µm spot size, and overhead air filtration and environmental control for enhanced functionality
  • Microarray scanner for fluorescence detection, 3 µm scanning resolution, intuitive graphical user interface, confocal optics, cyanine3 and cyanine5 dual detection, high-performance PMTs, 24-substrate autoloader, and ultra-high detectivity
  • Arrayit automated liquid handling robot with linear drive motion, optical encoders for ±1.0 µm positional resolution, 96-well and 384-well-dispense heads
  • Thermal cycler work stations, high-throughput PCR amplification, 384-well format, 6,144 PCR reactions per day
  • High-capacity freezer and refrigerator with –30°C and 4°C settings
  • Substrate baking oven
  • Dissecting microscope with 30X magnification
  • Vacuum-based sample preparation system
  • Arrayit hybridization and microarray processing system
  • High performance centrifuge with custom Arrayit rotor, thermal control and vacuum capabilities
  • Arrayit Microarray Substrates, 5,000 optically flat 25 x 76 mm with diagnostic coupling chemistry
  • Arrayit Hybridization Buffer, 200 vials (200 ml) of 1.25X solution
  • Arrayit Printing Buffer, 500 bottles (25 liters) of 2X solution
  • Arrayit protective nitrile cleanroom gloves (L, M, S), 5,000 each

Gold Laboratory Platform Package
Catalog: DGL
Starting price: $925,000

The Gold Laboratory Platform provides an On-Location Facility consisting of a state-of-the art microarray package containing a full line of the most advanced microarray and automation equipment in the world designed to genotype up to 1,000,000 patients per annum. The DGL Package includes the following:

  • One year license to use Arrayit VIP™ genotyping technology (US 6,913,879 and international equivalents)
  • One year license to use Arrayit patented printing technology (US 6,101,946 and international equivalents)
  • Complete laboratory protocols manual
  • Training and technical assistance
  • Three-month staffing to facilitate the technology transfer process
  • Oligonucleotide design software
  • Sample tracking and data analysis software
  • Microarray printing robot with 60-substrate platen, intuitive graphical user interface, optical encoders for ±0.5 µm positional resolution, calibrated substrate platen for high-precision travel distance, 48-pin printhead, 48 Micro Spotting Pins pins with 0.25 µl loading volume and 100-125 µm spot size, and overhead air filtration and environmental control for enhanced functionality
  • Microarray scanner for fluorescence detection, 3 µm scanning resolution, intuitive graphical user interface, confocal optics, cyanine3 and cyanine5 dual detection, high-performance PMTs, and ultra-high detectivity
  • Arrayit automated liquid handling robot with linear drive motion, optical encoders for ±1.0 µm positional resolution, 96-well and 384-well-dispense heads
  • Thermal cycler work stations, high-throughput PCR amplification, 384-well format, 3,072 PCR reactions per day
  • High-capacity freezer and refrigerator with –30°C and 4°C settings
  • Substrate baking oven
  • Dissecting microscope with 30X magnification
  • Vacuum-based sample preparation system
  • Arrayit hybridization and microarray processing system
  • High performance centrifuge with custom Arrayit rotor, thermal control and vacuum capabilities
  • Arrayit high-performance forced air forced air compressor with 0.1 µm filtration for topical decontamination
  • Arrayit Microarray Substrates, 2,000 optically flat 25 x 76 mm with diagnostic coupling chemistry
  • Arrayit Hybridization Buffer, 40 vials (40 ml) of 1.25X solution
  • Arrayit Printing Buffer, 100 bottles (5 liters) of 2X solution
  • Arrayit protective nitrile cleanroom gloves (L, M, S), 4,000 each

Silver Laboratory Platform Package

 Catalog: DSL
Starting price: $525,000

The Silver Laboratory Platform provides a Facility On-Location consisting of a state-of-the art microarray package containing a full line of the most advanced microarray automation equipment in the world designed to genotype 200,000 patients per annum. The DSL Package includes the following:

  • One year license to use Arrayit VIP™ genotyping technology (US 6,913,879 and international equivalents)
  • One year license to use Arrayit patented printing technology (US 6,101,946 and international equivalents)
  • Complete laboratory protocols manual
  • Training and technical assistance
  • One-month staffing to facilitate the technology transfer process
  • Oligonucleotide design software
  • Sample tracking and data analysis software
  • Microarray printing robot with 14-substrate platen, intuitive graphical user interface, ±10 µm positional resolution, calibrated substrate platen for high-precision travel distance, 4-pin printhead, 4 Micro Spotting Pins pins with 0.25 µl loading volume and 100-125 µm spot size, and environmental control for enhanced functionality
  • Microarray scanner for fluorescence detection, 3 µm scanning resolution, intuitive graphical user interface, confocal optics, cyanine3 and cyanine5 dual detection, high-performance PMTs, and ultra-high detectivity
  • Thermal cycler work stations, high-throughput PCR amplification, 384-well format, 1,536 PCR reactions per day
  • High-capacity freezer and refrigerator with –30°C and 4°C settings
  • Substrate baking oven
  • Dissecting microscope with 30X magnification
  • Vacuum-based sample preparation system
  • Arrayit hybridization and microarray processing system
  • Arrayit high-performance forced air forced air compressor with 0.1 µm filtration for topical decontamination
  • Arrayit Microarray Substrates, 500 optically flat 25 x 76 mm with diagnostic coupling chemistry
  • Arrayit Hybridization Buffer, 10 vials (10 ml) of 1.25X solution
  • Arrayit Printing Buffer, 25 bottles (1.25 liters) of 2X solution
  • Arrayit protective nitrile cleanroom gloves (L, M, S), 1,000 each

Bronze Laboratory Platform Package
Catalog: DBL
Starting price: $275,000

The Bronze Laboratory Platform provides an On-Location Facility consisting of a state-of-the art microarray package containing a full line of the most advanced microarray and automation equipment in the world designed to genotype up to 50,000 patients per annum. The DBL Package includes the following:

  • One year license to use Arrayit VIP™ genotyping technology (US 6,913,879 and international equivalents)
  •  
  • One year license to use Arrayit patented printing technology (US 6,101,946 and international equivalents)
  • Complete laboratory protocols manual
  • Training and technical assistance
  • One-week staffing to facilitate the technology transfer process
  • Oligonucleotide design software
  • Sample tracking and data analysis software
  • Microarray personal printing robot with 14-substrate platen, intuitive graphical user interface, calibrated substrate platen, 4-pin printhead, 4 Micro Spotting Pins with 0.25 µl loading volume and 100-125 µm spot size, and environmental enclosure for enhanced functionality
  • Microarray scanner for fluorescence detection, 10 µm scanning resolution, intuitive graphical user interface, confocal optics, cyanine3 and cyanine5 dual detection, and high detectivity capabilities
  • Compact refrigerator with 4°C setting
  • Substrate baking oven
  • Dissecting microscope with 30X magnification
  • Vacuum-based sample preparation system
  • Arrayit hybridization and microarray processing system
  • High performance centrifuge with custom Arrayit rotor, thermal control and vacuum capabilities
  • Arrayit Microarray Substrates, 250 optically flat 25 x 76 mm with diagnostic coupling chemistry
  • Arrayit Hybridization Buffer, 5 vials (5 ml) of 1.25X solution
  • Arrayit Printing Buffer, 10 bottles (500 ml) of 2X solution
  • Arrayit protective nitrile cleanroom gloves (L, M, S), 1,000 each